In a statement posted in English on her Instagram account late Sunday, Rodríguez urged the United States to engage with Venezuela on what she described as a development-focused agenda grounded in international law. "We call on the U.S. government to cooperate with us on an agenda oriented toward shared development, within the framework of international law, to strengthen lasting social coexistence,” she wrote.

Her comments came shortly after Trump warned that Venezuela could "pay a very high price” if it failed to meet U.S. demands, highlighting the heightened tensions between the two governments.

Meanwhile, a senior Venezuelan official said the government remained unified behind President Nicolás Maduro, amid uncertainty following reports that U.S. forces had detained him. Maduro is currently being held in New York ahead of a court appearance on drug-related charges, according to U.S. authorities.

In Caracas, senior officials loyal to Maduro continue to run state institutions, describing his arrest, along with that of his wife Cilia Flores, as a "kidnapping.” Interior Minister Diosdado Cabello, in an audio message released by the ruling United Socialist Party, called for calm and urged supporters not to respond to what he described as provocations.

Images circulating of the 63-year-old Maduro blindfolded and handcuffed during his transfer to the United States sparked widespread shock across Venezuela. Analysts have described the operation as one of the most controversial U.S. interventions in Latin America in decades.

Defense Minister Vladimir Padrino said on state television that the U.S. action resulted in the deaths of soldiers and civilians, as well as members of Maduro’s security detail, without providing further details. He added that the armed forces were on high alert to safeguard national sovereignty.

Rodríguez, who also serves as vice president and oil minister, assumed interim presidential duties with the approval of Venezuela’s Supreme Court, while maintaining that Maduro remains the country’s legitimate president. She also rejected claims attributed to Trump that she was prepared to cooperate with Washington under U.S. terms.

The Venezuelan government has repeatedly accused the United States of seeking control over the country’s vast natural resources, particularly its oil reserves. Venezuela, once among Latin America’s wealthiest nations, has suffered a prolonged economic collapse under Maduro, prompting millions of citizens to migrate in recent years.